Immune response far stronger in people who get vaccinated after they recover from COVID-19

Embargoed until: Publicly released: 2022-04-19 03:00

International

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Getting vaccinated after recovering from COVID-19 results in a substantially stronger immune response, according to international research. The team tested blood samples taken over a period of seven months to examine the antibody and T cell responses to the vaccine and how long they last. Comparing 118 COVID-19 recovered, vaccinated samples with 289 vaccinated samples without previous COVID-19 infection, the researchers say T-cell responses, anti-spike IgG responses
and neutralising antibodies were all enhanced in the COVID-19-recovered group when tested against 10 pre-Omicron variants.

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Journal/
conference: Clinical & Translational Immunology

Research:Paper

Organisation/s: Karolinska Institutet, Sweden

Funder: This work has been funded by the Jonas & Christina af Jochnick Foundation (to CT); Lundblad Family Foundation (to CT); Region Stockholm (to CT); Knut and Alice Wallenberg Foundation (to CT and SM); Jonas S€oderquist’s scholarship (to CT); Science for Life Laboratory (to PN); Erling-Persson Family Foundation (to SoH); Center for Innovative Medicine (to JK); and Swedish Research Council (to JK). The funders above had no role in the design and conduction of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication.

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