Expert Reaction

EXPERT REACTION: Two more deaths linked to the AstraZeneca vaccine

Publicly released:
Australia; NSW; QLD

The Therapeutic Goods Administration has been notified of two more fatal cases of the rare blood clotting disorder related to AstraZeneca's COVID-19 jab. The 44-year-old man from Tasmania and 48-year-old woman from Victoria were reported as probable thrombosis with thrombocytopenia syndrome (TTS) cases last week. Prime Minister Scott Morrison said yesterday that he has been making a “constant appeal” to vaccine advisory group ATAGI to change its advice to recommend the AstraZeneca jab to younger Australians. ATAGI's co-chair Christopher Blyth has previously said under 40s should only be considering getting AstraZeneca in "pressing circumstances".

Expert Reaction

These comments have been collated by the Science Media Centre to provide a variety of expert perspectives on this issue. Feel free to use these quotes in your stories. Views expressed are the personal opinions of the experts named. They do not represent the views of the SMC or any other organisation unless specifically stated.

Professor Robert Booy is an infectious diseases and vaccine expert with an honorary professorship at the University of Sydney and is a consultant to vaccine manufacturers.

The AZ vaccine has proven around the world to be a highly effective and safe vaccine.

However the occurrence of five deaths due to the clotting syndrome TTS, including two recent cases aged in their 40s, has led us at the Immunisation Coalition to support the position of ATAGI that the A/Z vaccine should be given to people aged 60 and above; and used only after consultation for younger adults in places where COVID-19 is widely spreading.

Now that we have in Australia a reliable supply of at least one million Pfizer doses per week, there is an alternative. An abundance of caution should be observed.

Last updated:  22 Jul 2021 5:46pm
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Declared conflicts of interest Robert consults to vaccine manufacturers including CSL, GlaxoSmithKline, Merck Sharp & Dohme and Sanofi Pasteur.

Professor Raina MacIntyre is Head of the Biosecurity Program at the Kirby Institute at the University of NSW. She is an expert in influenza and emerging infectious diseases.

We published a risk analysis for people under 60 years in Australia, which shows the benefits clearly outweigh the risk in people over 60, but may not do so in people under 60 years.

Last updated:  03 Aug 2021 12:31pm
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Declared conflicts of interest Raina MacIntyre has consulted for or been on advisory boards for Sanofi, Seqirus, Janssen and AstraZeneca in the past 12 months.

Dr Roger Lord is a senior lecturer (Medical Sciences) with the Faculty of Health Sciences at The Australian Catholic University and Visiting Research Fellow with The Prince Charles Hospital (Brisbane)

The recent report of two more fatal cases of thrombocytopenia syndrome (TTS), a rare blood clotting disorder associated with the AstraZeneca COVID-19 vaccine, will further fuel vaccine hesitancy in the younger community.

This is further compounded by the political entanglements associated with medical advice provided by ATAGI and the Prime Minister’s desperate attempt to challenge these recommendations.

If the PM wishes to overrule the expert recommendations on the basis of the increased risk of COVID-19 transmission of the Delta variant then he should make this decision independently.

He cannot realistically expect ATAGI to alter its recommendations on which age group should receive the AstraZeneca vaccine.

The approach currently appears to be at a political stalemate and may require the public to make an informed decision for themselves.

The risk of developing the rare TTS if vaccinated with AstraZeneca is far less than the serious illness and hospitalisation likely if an individual remains unvaccinated. 

The increasing cases of COVID-19 Delta variant in NSW and Victoria mean a significant increase in risk of infection.

Vaccination is the key to lower transmission and severe illness caused by this variant.

Last updated:  22 Jul 2021 5:43pm
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Declared conflicts of interest None declared.
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