European ancestry linked to greater bowel cancer risk

Embargoed until: Publicly released: 2026-08-13 01:00

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A US study has found that having European ancestry is linked to a greater risk of developing colorectal cancer, although differences in health, behaviour, and family history had a bigger impact on colorectal cancer risk. The study, which looked at data from over 300,000 people, also found that having American admixed-Latino and East Asian ancestry was linked with earlier diagnosis and higher risk at a specific age.

News release

From: JAMA

Genetic Ancestry and Colorectal Cancer in the All of Us Dataset

In this cohort study, genetic ancestry was associated with meaningful differences in CRC burden and age-specific risk. These findings suggest that a multiethnic XGBoost model may complement CRC screening as a risk-enrichment tool.

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Journal/
conference: JAMA Network Open

Research:Paper

Organisation/s: The Ohio State University Wexner Medical Center, USA

Funder: The All of Us Research Program is supported by the National Institutes of Health, Office of the Director (Regional Medical Centers, 1 OT2 OD026549, 1 OT2 OD026554, 1 OT2 OD026557, 1 OT2 OD026556, 1 OT2 OD026550, 1 OT2 OD 026552, 1 OT2 OD026553, 1 OT2 OD026548, 1 OT2 OD026551, 1 OT2 OD026555, and IAA AOD 16037; Federally Qualified Health Centers; HHSN 263201600085U; Data and Research Center, 5 U2C OD023196; Biobank, 1 U24 OD023121; The Participant Center, U24 OD023176; Participant Technology Systems Center, 1 U24 OD023163; Communications and Engagement, 3 OT2 OD023205 and 3 OT2 OD023206; and Community Partners, 1 OT2 OD025277, 3 OT2 OD025315, 1 OT2 OD025337, and 1 OT2 OD025276).

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