Early changes in the COVID-19 virus help explain why death rates dropped as the pandemic progressed

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Early changes to the COVID-19 virus were associated with increased survival once a patient was hospitalised, according to a US study. Researchers analysed the health outcomes of 302 COVID-19 patients during the first wave of infection in Cleveland Ohio and the variants they were infected with. They found no variants were associated with a higher hospitalisation rate or admission to ICU, but the more contagious variants were associated with a better chance of survival once in hospital. Over the course of the study, researchers observed the more contagious variants becoming more common in comparison to other variants.

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From: JAMA

The association of identified SARS-CoV-2 variants and virus groupings with disease severity and patient outcomes is evaluated in this study.

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conference:
JAMA Network Open
Research:Paper
Organisation/s: Cleveland Clinic Children’s, USA
Funder: This project was supported in part by National Science Foundation grants IIS-2027667 (to Drs J. Li and Esper), CCF-2006780 (to Dr J. Li), CCF-1815139 (to Dr J. Li), and NS097719 (to Dr J. Li), and through unrestricted funds from the Robert J. Tomsich Pathology and Laboratory Medicine Institute.
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