Dementia risk could be more than doubled for people with depression

Embargoed until: Publicly released: 2023-07-25 01:00

International

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Men and women with diagnosed depression could have more than twice the risk of developing dementia, according to international research. Using population-wide Danish health data, the researchers matched nearly 250,000 people with diagnosed depression with over 1 million people without depression, and compared dementia rates. They say the risk of dementia was 2.41 times higher for those with a depression diagnosis, and this heightened risk remained regardless of whether they were diagnosed with depression in early or middle life.

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Journal/
conference: JAMA Neurology

Research:Paper

Organisation/s: Aarhus University, Denmark

Funder: Dr Gradus reported receiving personal fees from Peabody Arnold and having patent for use of glecaprevir/ pibrentasvir for the treatment of posttraumatic stress disorder pending. Dr Smith reported receiving personal fees from US Food and Drug Administration outside the submitted work. Dr Lash reported receiving grants from the National Institutes of Health during the conduct of the study and personal fees from Amgen outside the submitted work. Dr Glymour reported receiving grants from the National Institutes of Health/ National Institute on Aging outside the submitted work. Dr Henderson reported receiving grants from the National Institutes of Health and reviewer honoraria from Institute for Clinical and Economic Review on dementia topics outside the submitted work. No other disclosures were reported.

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