COVID-19 may increase the risk of type 1 diabetes in kids

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US scientists say catching COVID-19 may make children more likely to develop type 1 diabetes. Diagnoses of the disease increased during the COVID-19 pandemic, so the researchers set out to see if kids who had contracted COVID-19 were more likely to receive a subsequent type 1 diabetes diagnosis than children with other respiratory diseases. They looked at data for 1,091,494 US kids, 314 917 of whom had contracted COVID-19 and 776,577 of whom had not contracted COVID-19 but had caught other respiratory infections. Six months after infection, 123 kids in the COVID-19 group (0.043%) had received a diagnosis of type 1 diabetes, while only 72 (0.025%) in the non-COVID-19 group had. At three time points investigated - one, three and six months - kids with COVID-19 were more likely to have type 1 diabetes than those in the non-COVID-19 group. Although this type of study can't show that COVID-19 actually caused the increased risk of type 1 diabetes, the findings raise concern for long-term, post–COVID-19 autoimmune complications in children, the scientists say.

Media release

From: JAMA

Association of SARS-CoV-2 Infection With New-Onset Type 1 Diabetes Among Pediatric Patients

About The Study: New type 1 diabetes diagnoses were more likely to occur among pediatric patients with prior COVID-19 than among those with other respiratory infections in this study, but researchers acknowledge study limitations that include the observational and retrospective design of the electronic health record analysis and the possibility that additional unidentified factors accounted for the association.

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Research JAMA, Web page The URL will go live after the embargo ends
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conference:
JAMA Network Open
Research:Paper
Organisation/s: Case Western Reserve University, USA
Funder: This study was supported by grants AG057557 (Dr Xu), AG061388 (Dr Xu), AG062272 (Dr Xu), and AG076649 (Drs Xu and Davis) from the National Institute on Aging; grant R01AA029831 (Drs Xu and Davis) from the National Institute on Alcohol Abuse and Alcoholism; grant UG1DA049435 from the National Institute on Drug Abuse, and grant 1UL1TR002548-01 from the Clinical and Translational Science Collaborative of Cleveland.
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