New insights into liver regeneration revealed in mouse study

Embargoed until: Publicly released: 2025-01-16 11:00

Australia; VIC

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WEHI researchers have uncovered how liver cells, or hepatocytes, regenerate and repair the liver. Using advanced mouse models, they identified two main cell zones, near the centre of the liver and near the edges, each playing a unique role in liver health. In adults, these cells mostly self-maintain within their zones but can adapt to regenerate damaged areas when needed. This discovery could pave the way for better understanding of liver diseases, including liver cancer, and help develop new treatments in the future.

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Research Cell Press, Web page

Journal/
conference: Cell Reports

Research:Paper

Organisation/s: WEHI, The University of Melbourne

Funder: This work was supported by NMRC OF-YIRG (MOH-000546), the Gilead Research Scholars Liver Disease Program (Asia) (2020-Gilead-001), NHMRC Ideas Grant (#2037907), and Khoo Bridge Funding Awards. N.Y.F. and C.H.A. were supported by Victorian Cancer Agency Mid-Career Research Fellowship (MCRF22013) and NMRC OF-YIRG (MOH-000935), respectively; G.K.S. was supported by an NHMRC Fellowship (#1058892) and Investigator Grant (#2025645); and Y.C. was supported by an MRFF Investigator Grant (#1176199).

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