Bipolar study finds new genetic links to the disorder

Embargoed until: Publicly released: 2021-05-18 01:00

Australia; International; NSW; QLD

A genetic study of 41,917 people with bipolar disorder has identified genetic links to schizophrenia and major depression. In the study, International and Australian researchers identified 64 genetic locations associated with bipolar disorders, 33 of which were new discoveries. 27 of the 64 genetic locations have previously been linked to schizophrenia, while seven have been linked to major depression. The study found Bipolar 1 was more genetically correlated with schizophrenia, while Bipolar 2 is more strongly correlated with major depression.

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Journal/
conference: Nature Genetics

Research:Paper

Organisation/s: The University of Queensland, The University of Newcastle, The University of New South Wales, The University of Melbourne, The University of Western Australia

Funder: The PGC has received major funding from the US National Institute of Mental Health (PGC3: U01 MH109528; PGC2: U01 MH094421; PGC1: U01 MH085520). Statistical analyses were carried out on the NL Genetic Cluster Computer http://www.geneticcluster.org) hosted by SURFsara and the Mount Sinai high-performance computing cluster (http://hpc.mssm.edu), which is supported by the Office of Research Infrastructure of the National Institutes of Health under award numbers S10OD018522 and S10OD026880.

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