Better understanding the role of fibroblasts in breast cancer development

Embargoed until: Publicly released: 2025-04-17 12:00

Australia; VIC

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A WEHI research team has analysed over 45,000 fibroblasts (supportive cells) in mice to see how these change over time, finding that there are many types of fibroblasts, and that these change as the breast develops. In tumours, these cells can turn into cancer-associated fibroblasts (CAFs), with one particular type of these cells showing signs of ageing that could aid tumour growth. Understanding the diversity of fibroblasts and how they change over time could lead to new ways to diagnose or treat breast cancer.