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Small study suggests quick, cheap home COVID-19 tests are as effective as PCR testing

Embargoed until: Publicly released:
Peer-reviewed: This work was reviewed and scrutinised by relevant independent experts.

Observational study: A study in which the subject is observed to see if there is a relationship between two or more things (eg: the consumption of diet drinks and obesity). Observational studies cannot prove that one thing causes another, only that they are linked.

People: This is a study based on research using people.

US scientists set out to compare the performance of rapid, cheap home COVID-19 tests called 'direct antigen rapid tests' (DARTs) with lab-based  'quantitative real-time polymerase chain reaction' (qRT-PCR) tests on self-collected nasal specimens from 257 people. The participants tested themselves twice weekly for six months using the DART tests, and the results were compared with qRT-PCR tests. During the study period, 15 participants caught COVID-19, and the DART tests picked up all 15 cases. In one case, PCR detected COVID-19 one day before the DART test, but in another, the DART test detected the disease one day before the PCR test. Regularly using DART tests at home would allow infected individuals to be identified and quarantined immediately, the authors say, which could prevent viral transmission at work or in other social settings.

Journal/conference: JAMA Network Open

Link to research (DOI): 10.1001/jamanetworkopen.2021.26931

Organisation/s: BioLabs (BioInnovation Labs, LLC), USA

Funder: Funding was provided by E25Bio, Inc, LabCentral, Inc, and BioLabs, LLC, in 3 equal parts. The 3 funding entities formed the Cambridge Consortium for Rapid COVID-19 Tests and were each involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

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